• The different number of chromosomes in Przewalski's horse and domestic horses raises doubts about its origin. Because of this difference, the previous belief that Przewalski's horse was the main ancestor of domestic horses now seems unlikely.
• The limited gene pool of Przewalski's horses leads to frequent inbreeding, which reduces their viability and reproductive ability. In captivity, this is worsened because wild horses in nature constantly move, covering many kilometers per day.
• Hybrids of Przewalski's horses usually do not survive due to unsuitable food. They die or fail to reproduce because of poor nutrition.
• Domestic horses and Przewalski's horse can interbreed freely and produce fertile offspring, unlike other horse genus species hybridizations. Male hybrids of other horse genus species are always sterile.

The species is a terrestrial animal, inhabiting and developing on land, away from bodies of water, and giving birth to live young that are not hatched from eggs or spawn. The female’s gestation period lasts eleven months and three weeks, resulting in a single foal, which she delivers on the ground. The mother feeds and protects the foal for several months. The species reproduces through homogamy, always with fertilization and without generational change. The size of the offspring is one. Maturity occurs from 2 to 5 years of age. The interval between breeding periods is from 1 to 2 years.