• The red-tailed phascogale does not have full pouches, but before giving birth, it develops skin folds with 8 nipples to protect its offspring. These folds develop specifically before the birth of the young.
• The red-tailed phascogale gives birth to up to 8 young between June and August. Males die soon after mating with females.
• Males die en masse after their first mating due to stress, so they usually live no more than 11–12 months.
• The female gives birth to up to 13 young but can raise only eight (matching the number of teats).

Red-tailed mousesacks inhabit terrestrial environments and develop exclusively on land, away from bodies of water; embryonic development lasts 5 days, and the female carries very small young in a pouch or mouth. A litter has 6 to 8 offspring, and reproduction occurs once per year. The interval between reproductive events is from 1 year to 1 year and 1 month. Young develop in a pouch or mouth on land, and eggs or young also develop in nests built on or near the ground, or high in the branches of shrubs or trees. Sexual reproduction is homogamous, always involving fertilization without generation changes; males frequently die after the breeding season. The female reaches maturity from 9 months and 1 week to 11 months.